NFAT5 moves to Fat City

Immunodeficiency and autoimmune enterocolopathy linked to NFAT5 haploinsufficiency.

The link between autoimmune diseases and primary immunodeficiency syndromes has been increasingly appreciated. Immunologic evaluation of a young man with autoimmune enterocolopathy and unexplained infections revealed evidence of immunodeficiency, including IgG subclass deficiency, impaired Ag-induced lymphocyte proliferation, reduced cytokine production by CD8(+) T lymphocytes, and decreased nu...

EHP Moves to Open Access

loss of global biodiversity, namely a reduction in the variety of life on Earth, is rarely given much attention by physicians or environmental scientists. Like most people, they do not spend much time thinking about their relationship to other life forms, and they generally act, unknowingly, as if human beings were separate from the rest of nature—as if we could change the composition of the at...

Achieving built-environment and active living goals through Music City Moves.

BACKGROUND Nashville, Tennessee, formed Music City Moves (MCM), an interdisciplinary, countywide partnership to implement its vision for the community: a metropolitan region where routine physical activity is a fundamental part of daily life for all residents. INTERVENTION Music City Moves' main focus was the pursuit of changes in community planning policies to help shape Nashville's built en...

Innate DNA sensing moves to the nucleus.

It has been assumed that cells distinguish viral from cellular DNA due to the former's presence in the cytosol. However, in this issue, Kerur et al. (2011) propose that the DNA genome of Kaposi's sarcoma-associated herpesvirus (KSHV) is recognized inside the nucleus by the DNA sensor IFI16, leading inflammasome activation.

Robot Programming - From Simple Moves to